Chelsea head to Old Trafford hoping victory will move them level with Man United at the top of the Premier League and give them a chance of winning the unlikeliest of Premier League trophies.
Here are six of the best end of season title showdowns from recent history...
Liverpool 0-2 ARSENAL 1988-89
The mother of all title deciders saw Arsenal travel to Anfield needing to win by two goals in order to equal Liverpool's points tally and goal difference for the season and win the league courtesy of goals scored. As fate would have it, the face-off was the last Football League game of the entire season (before the days when all clubs in a division played their finals games at the same time), so the whole country's eyes were on Anfield. Liverpool were kings of English football at the time and heading for the Double having already won the FA Cup, making the Gunners - seeking a first title in 18 years - big underdogs beforehand. Despite Arsenal leading 1-0 as the match entered its final minute the game seemed to be up, leading co-commentator David Pleat to declare that, "Although Arsenal aren't going to win the Championship, it is somewhat poetic justice that they have a result on the night." At which point Michael Thomas burst through, commentator Brian Moore declared "It's up for grabs now!" and the midfielder buried Arsenal's second to bring the title back to London.
Newcastle 0-1 MAN UNITED 1995-96
With ten games remaining this win for United was a huge step in a monumental comeback that saw them close a 12 point gap on Newcastle from January and eventually win the league. Newcastle dominated the game but Peter Schmeichel's heroics and Eric Cantona's second half volley handed United all three points and proved a major turning point in the home straight. Kevin Keegan definitely didn't love it.
MAN UNITED 0-1 ARSENAL 2001-02
Trailing the Gunners by five points ahead of this penultimate league fixture, United had to win to keep their Premier League hopes alive, but Arsenal finished the job at Old Trafford with a 1-0 win thanks to this second half strike from Sylvain Wiltord.
CHELSEA 2-1 MAN UNITED 2007-08
A win for Chelsea put them level on points with United with two games to play but the Blues could only manage a draw with Bolton on the last day of the season. United, meanwhile won their remaining two games as well as that famous Champions League shoot-out in Moscow, but the match at the Bridge is possibly better remembered for the fight between Patrice Evra and one of Chelsea's groundsmen during United's warm down.
MAN UNITED 1-4 LIVERPOOL 2008-09
Liverpool's emphatic win at Old Trafford kick-started their hopes of a first league crown since 1990 as they closed the gap on United to four points with nine games to play. Cristiano Ronaldo gave the home side the lead from the spot but after Fernando Torres and Steven Gerrard replied in the first half, Fabio Aurelio and Andrea Dossena put the gloss on a famous Liverpool victory - although United bounced back to claim a second successive Premier League trophy by four points.
MAN UNITED 1-2 CHELSEA 2009-10
With five games to play, Chelsea moved two points clear of Man United with a victory at Old Trafford thanks to a cheeky flick by Joe Cole and a second half winner from Didier Drogba - a result which effectively handed Carlo Ancelotti his first Premier League trophy given they finished the season just one point clear of the Red Devils.