Ospreys prop Aaron Jarvis will make his international debut in Wales' autumn Test series opener against Argentina at the Millennium Stadium.
Rob Howley has surprised many by announcing that Scarlets star Tavis Knoyle will start at scrum-half instead of British and Irish Lions Test number nine Mike Phillips.
There are seven changes from Wales' last game - a 20-19 defeat to Australia in Sydney last June - with Williams, Roberts, Knoyle, Jarvis, lock Ian Evans, Turnbull and number eight Toby Faletau all starting.
"One or two injuries have forced our hands in certain areas in terms of selection," Howley said.
"But the fact that we are still able to field a side packed with Grand Slam experience shows that we have been able to develop some depth in recent years.
"There are obvious opportunities for the likes of Aaron, Tavis and Josh to pull on the jersey against Argentina and try to make it their own.
"We all know how important a good start against the Pumas will be to our November series. They arrive battle-hardened after a tough Rugby Championship campaign.
"They will be looking to silence the Millennium Stadium crowd from the outset and we know we can't afford to let that happen, with a successful campaign this autumn vital to our ambitions for the future."
Wales team to play Argentina at the Millennium Stadium on Saturday:
L Halfpenny (Cardiff Blues); A Cuthbert (Cardiff Blues), S Williams (Scarlets), J Roberts (Cardiff Blues), G North (Scarlets); R Priestland (Scarlets), T Knoyle (Scarlets); G Jenkins (Toulon), M Rees (Scarlets), A Jarvis (Ospreys), A-W Jones (Ospreys), I Evans (Ospreys), J Turnbull (Scarlets), S Warburton (Cardiff Blues, capt), T Faletau (Newport Gwent Dragons).
Replacements: R Hibbard (Ospreys), R Bevington (Ospreys), P James (Bath), R McCusker (Scarlets), J Tipuric (Ospreys), M Phillips (Bayonne), J Hook (Perpignan), L Williams (Scarlets).